The PHD2 oxygen sensor paves the way to metastasis
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چکیده
منابع مشابه
The PHD2 oxygen sensor paves the way to metastasis
Breast cancer is the most frequent cancer and remains the second leading cause of cancer death in women. Metastatic relapse is a main cause of this high mortality. Understanding the mechanisms that control metastasis is therefore pivotal for the design of improved and safe breast cancer treatment regimen. Hypoxia is a characteristic feature of most solid tumors, including breast cancer, and is ...
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Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2) in cancer have not been addressed. First, the role of PHD2 in metastasis has not been studied in a spontaneous tumor model. Here, we show that global PHD2 haplodeficiency reduced metastasis without affecting tumor growth. Second, it is unknown whether PHD2 regulates cancer by affecting cancer-associated fibroblast...
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Mathieu P. Rodero and Yanick J. Crow Laboratory of Neurogenetics and Neuroinflammation, Paris Descartes–Sorbonne Paris Cité University, INSERM UMR 1163, Institut Imagine, Hôpital Necker, Paris 75015, France; and Manchester Centre for Genomic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manc...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.6216